Thomson Healthcare, Inc.
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 Sixty-three patients were randomized to receive a water-soluble cream (30 mg/g of glucosamine sulfate; 50 mg/g of chondroitin sulfate, 140 mg/g of shark cartilage, 32 mg/g of camphor, and 9 mg/g of peppermint oil) or placebo for 8 weeks. Both groups reported improvement on the visual analog scale pain scores, with the treatment group improving a further 1.2 points (p=0.03) at 4 weeks and 1.8 points (p=0.002) at 8 weeks compared to the placebo group. |
Dr. Steve Blake
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 Special supplements for joint and bone health may contain large amounts of manganese ascorbate along with chondroitin sulfate and glucosamine hydrochloride. This type of supplement has been found to relieve pain in some cases of mild to moderate osteoarthritis of the knee.
MANGANESE TOXICITY
Manganese toxicity from food alone has not been reported, although some diets provide as much as 20 mg daily. The Food and Nutrition Board has set a rather conservative tolerable upper intake level (UL) of 11 mg for adults. The UL for children ranges from 2 mg to 6 mg and the UL for adolescents is 9 mg. |
Thomson Healthcare, Inc.
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| Similar efficacies were demonstrated for chondroitin and glucosamine on the Lequesne Index (LV, and visual analog scale (VAS) for pain and mobility. Join cartilage degeneration was slowed by the long-term daib administration of oral glucosamine at the minimal dose o 1,500 mg during a minimal period of 3 years (Richy et e
2003). An earlier meta-analysis of 16 randomized, controlled trials found glucosamine to be safe and effective for the treatment of osteoarthritis. In 12 of 13 studies comparing it to placebo, glucosamine demonstrated superior pain relief. |
Bill Sardi
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 Breast cancer and chondroitin ... 421
Size of HA and cancer... 421
Blocking the cancer receptor site ... 421
Cancer find hailed ... 422
HA drug combo ... 423
Summary... 424
Does hyaluronic acid promote or accelerate the spread of cancer? ... 424
Melatonin: The sleep hormone that prolongs survival... 425
Melatonin as cancer therapy ... 427
Supplemental melatonin helps overcome symptoms during cancer treatment... 427
What impairs melatonin production? ... 427
Melatonin and chemotherapy side effects... 428
Cancer patients and sleep problems ... 428
Melatonin enhancement... |
Phyllis A. Balch, CNC
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 Glucosamine may be taken in conjunction with chondroitin sulfate for an even greater effect on osteoarthritis (see chondroitin Sulfate in this section).
In addition to having benefits for people with osteoarthritis, supplemental glucosamine can be helpful for asthma, bursitis, candidiasis, food allergies, osteoporosis, respiratory allergies, tendinitis, vaginitis, and various skin problems. The product GS-500 from Enzymatic Therapy is a good source of glucosamine. |
Thomson Healthcare, Inc.
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| Richy F, Bruyere O, Ethgen O et al: Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis. Arch Intern Med; 163(13): 1514-1522. 2003
Rindone JP, Hiller D, Collacott E, et al. Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med. Feb;172(2):91-4. 2000.
RTECS: Registry of Toxic Effects of Chemical Substances. National Institute for Occupational Safety and Health, Cincinnati, OH (internet version), Thomson Micromedex, Greenwood Village, CO; 2001. |
Mark Stengler, N.D.
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 Ever since publication of The Arthritis Cure, people have asked about the benefits of taking glucosamine sulfate and chondroitin sulfate together. In my experience, I've found that most people do well by just supplementing with glucosamine sulfate—and there have been fewer studies on the chondroitin sulfate. Occasionally, however, when 1 have a patient who doesn't respond so well as I would like to glucosamine sulfate, I'll also recommend a combination with chondroitin sulfate—and sometimes the two, taken together, produce a better effect. |
Dr. Gary Null
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 A study of chondroitin polysulfate showed that serum cholesterol was 10-20 percent lower and triglycerides were 27 percent lower for a treated group, as opposed to controls. Mean clotting time increased by 50 percent after 33 months of treatment.
K. Nakazawa and K. Murata, "The Therapeutic Effect of chondroitin Polysulfate in Elderly Athersclerotic Patients," Journal of International Medical Research 6, no. 3 (1978): 217-25.
Chondroitin-4 sulfate prolonged thrombus formation and reduced serum cholesterol, a study of 120 coronary heart disease patients showed. |
Mark Stengler, N.D.
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| In my experience, I've found that most people do well by just supplementing with glucosamine sulfate—and there have been fewer studies on the chondroitin sulfate. Occasionally, however, when 1 have a patient who doesn't respond so well as I would like to glucosamine sulfate, I'll also recommend a combination with chondroitin sulfate—and sometimes the two, taken together, produce a better effect.
There's certainly no harm in trying the combination (though cost may be a consideration). The daily dosage recommended for chondroitin sulfate is 1,200 milligrams. |
Earl Mindell, R.Ph., Ph.D.
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 Several clinical studies, all performed outside the United States, clearly showed that when arthritic patients were given chondroitin sulfates, they not only experienced significant relief in pain and an increase in mobility but felt positive effects long after they discontinued taking the chondroitin. This is good evidence that the treatment did not simply mask the pain but actually helped to restore lost cartilage.
Several other supplements in the Hot 100 can also help reduce the inflammation and pain typical of arthritis, and they can be used with glucosamine, chondroitin, and pregnenolone. |
Joseph E. Mario
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 Reduce the Irontakenwith Fatty acids forming peroxides with the unabsorbable ferric (risking heart attack) by taking Vitamin C, also helping to make body chondroitin Sulfate-A, healthful artery wall cement. Oxygen, Enzymes, and oxidizing chemicals in smog turn unsaturated Fatty acids into peroxides; take antioxidant VitaminsE, B-Complex, B6. Chromium. Potassium, and Bee Pollen. |
Henry Pasternak, D.V.M., C.V.A.
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 Glycosaminoglycans (chondroitin-4-sulfate, dermatan sulfate, chondroitin-6-sulfate, heparin sulfate, chondroitin polysulfate, heparin, and hyaluronic acid) make up 10-15 percent of perna.
Perna seems to enhance the regenerative pathways of the cell, including the chondrocytes (cartilage cells) in the synovial membranes. It increases the biological uptake and production of natural substances such as the sulfated GAGs and hyaluronic acid, which are already present in healthy joints. Hyaluronic acid's key role is to help maintain proper lubrication and viscosity within the synovial cavity. |
Bill Gottlieb
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 GLUCOSAMINE AND CHONDROITIN: For Older Workers
The supplements glucosamine and chondroitin can help decrease the aches and pains of RSI, particularly in older data-entry workers, Dr.
Markison says. He recommends a supplement with 500 milligrams of glucosamine and 400 milligrams of chondroitin; take three a day if you weigh more than 110 pounds and two a day if you weigh less.
WATER: 64 Ounces a Day Is Essential
Staying well-hydrated boosts the circulation of the body pushing pain-relieving oxygen and nutrients into the areas hit by RSI, Dr. Markison says. |
Carol Simontacchi
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 Carlisle, PhD verified silica's role in connective tissue formation, noting that silica is a structural component of glycos-aminoglycans (hyaluronic acids, chondroitin sulfates, and keratin sulphate) and their glycoprotein complexes. Carlisle noted that with the departure of silica from the interior (intimae) of artery walls and with the
SierraSil—A Unique Mineral Supplement
Recently, a new mineral supplement emerged on the market, providing a unique combination of vital nutrients. This product has been shown to relieve arthritic pain and reduce inflammation. |
Dr. Mary Dan Eades
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 Recommendation: If you weigh less than 120 pounds, take 1000 mg glucosamine plus 800 mg chondroitin sulfates. If your weight falls between 120 and 200 pounds, take 1500 mg glucosamine plus 1200 mg chondroitin sulfates. Anyone over 200 pounds should take 2000 mg glucosamine and 1600 mg chondroitin sulfates. Everyone's needs vary, so be sure to have a thorough consultation with a physician and make clear your intent to follow this treatment.
• Niacin appears to decrease pain and increase mobility of painful joints after as little as 2 to 6 weeks of supplementation. |
Carol Simontacchi
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| The Recommended Doses
The standard recommended dosage for these supplements is 1,500 mg of glucosamine and 1,200 mg of chondroitin per day, divided into several doses.
ESSENTIAL MINERALS
Every cell in the body depends on minerals. Minerals are needed for the proper composition of body fluids, the formation of blood and bone, the maintenance of healthy nerve function, and the regulation of muscle tone. Minerals are considered coenzymes, which means that they enable the body to perform all of its many functions—including all functions relating to the control of inflammation. |
James A. Duke, Ph.D.
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 I've yet to see any suggestion that glucosamine or chondroitin causes any problems when taken in the recommended doses.
Unfortunately, only about half of the people who use glucosamine and chondroitin experience noticeable improvement in their osteoarthritis symptoms. So I'm inclined to agree with the experts who suggest trying these supplements for a few months. If they help, keep taking them. If not, stop.
Glucosamine and chondroitin are available wherever supplements are sold. |
Mike Adams, the Health Ranger
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 This is not chondroitin sulfate, or glucosamine, or MSM, or any of the other more common nutritional supplements you might typically take for joint health. Rather, these affect inflammation and joint pain through a different mechanism. They help inhibit the inflammatory response in the human body by fundamentally balancing the body's systems. They're not treating symptoms; they're balancing the body. Both rosemary and turmeric are well known for their tonic effects.
Turmeric also has the advantage of being a potent anti-cancer herb. |
The Editors of FC&A
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| People in most studies took 1,500 milligrams (mg) of glucosamine each day - usually 500 mg three times a day, and 1,200 mg of chondroitin every day - or 400 mg three times a day. They work slowly, so you may have to take them for two or three months before you feel results.
Since glucosamine is made from crab shells, you may want to skip it if you're allergic to shellfish. It may also raise your blood sugar if you have diabetes, so monitor yourself carefully. |
Mark Hyman, M.D.
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 Like glucosamine, chondroitin is found in the normal joint fluid, and it may act as a lubricant of sorts. As a supplement, it is obtained from either cow cartilage or from crustaceans' shells.
The glucosamine-chondroitin combination, one of our favorite pro-drugs, works by improving the body's formation of cartilage, and also by reducing inflammation of the joints themselves.
Another pro-drug is N-acetyl cysteine, or NAC, a naturally occurring amino acid compound found in the body that augments and improves the body's normal mechanisms that thwart illness and disease. |
| She read them, and soon started taking 1,500 mg of glucosamine and 1,200 mg of chondroitin sulfate daily in three divided doses.
Three months later her knee pain and stiffness were completely gone, and she was back to playing tennis and golf. She was even ballroom dancing again. She felt so good that she'd begun giving her pet poodle, Maxine, some glucosamine and chondroitin, and Maxine's response was similar to hers. Neither of them, noted Sylvia, experienced any side effects. |
Mike Adams
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 ArthroMax, Super Curcumin with Bioperine, Glucosamine Sulfate, chondroitin Sulfate, Super EPA / DHA with Sesame Lignans and Olive Fruit Extract (www.LEF.org)
*" Joint Support Liquid Concentrate (www.Eidon.com)
Hyaluronic Acid (www.WellnessResources.com)
Kidney stones
Like most other diseases and conditions mentioned here, kidney stones are also preventable. What causes kidney stones? The short answer is: Drinking soft drinks, coffee, and lots of tea. Kidney stones are formed through a variety of biochemical processes, but those are the primary foods and beverages that cause kidney stones. |
Joseph E. Mario
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| Glucosamine is in chondroitin Sulfate, and shark cartilage products, but the Glucosamine is bound in chains with attached sugars 250 times larger than a single molecule of GS for difficult absorption (counter with Enzymatic Therapy's GS-500 with 98% absorption). Less easily utilized N-Acetyl Glucosamine (NAG) from an acetic acid molecule instead of Sulfur, L-Glutamine, and Glucose, is broken down or deacetylated by intestinal bacteria, and binds with lectins for elimination in the feces; and Aminosugar Glucosamine Hydrochloride. |
Mike Adams
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| This should also be combined with a long-term nutritional program of glucosamine, chondroitin sulfate, MSM and other supporting supplements that can help joint function in a healthful way over the long term. Although these substances don't work very well in the short term to treat acute arthritis pain, they do help your body solve the underlying nutritional problem.
Arthritis sufferers should especially avoid hydrogenated oils. Hydrogenated oils are toxic to the human body. They contain trans-fatty acids. |
| Cucumber juice is one of my highly recommended plant-based medicines for reducing joint pain, and there are many herbs that reduce joint pain in the short term such as boswellia, cherry extract, MSM, glucosamine, and chondroitin sulfate.
From the plant world, the best foods are cherries (about 1 container a day)—which contain anti-inflammatory compounds. They are natural inflammation inhibitors that, for many people, actually work better than prescription drugs. Just keep in mind that when you're dealing with joint pain, these natural remedies are not instant painkillers. |
Kevin Trudeau
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 Hyaluronic Acid Complex with chondroitin recently found to be more effective than glucosamine.
Whole Food Green Powder, Vitamineral Green www.livingnutritionals.com (800) 642-4113 loint and Muscle Comfort Plus, Dr. Julian Whitaker www.drwhitaker.com (800)211-6358
Alpha-flex with Omeage-5e, Alpha-flex www.alphaflex.net (800) 877-1269
Joint Advantage, Mountain Home Nutritionals (800) 888-1415
Flexanol, NorthStar Nutritionals (800)311-1950
Advanced loint Support, Healthy Resolve (800) 728-2288
Bone Revitalizer www.drlark.com (888) 314-5275
Alleviate www.instituteforvibrantliving. |
Carol Simontacchi
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| The Science Behind It
Glucosamine and chondroitin have been studied for many years. The research performed on these natural anti-inflammatories includes the following:
In a study of 414 women with osteoarthritis of the knee, women taking 1,500 mg of glucosamine sulfate (GS) daily experienced no further loss in cartilage tissue, while the placebo group continued to experience cartilage destruction. The women taking the GS supplement also experienced a reduction in pain and an improvement in function. |
Bill Sardi
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| Blocking the cancer receptor site
The Winnipeg Free Press in Canada reported a startling story of widespread interest on July 15th, 1995. The report said Manitoba scientists found they can stop the spread of cancer in mice by turning off a cancer cell's sensing ability. Sensors, called receptor sites, on the surface of living cells, are able to be knocked out and completely block the spread of a tumor. The knocked-out receptors later return to normal when the cancer risk has subsided. It's like pulling blinders over a cell. Tumor cells just die once they are blinded. |
Michael Friedman, ND
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 Calcium Caution: Lipids are negatively charged ions and so is the phosphate P04-and chondroitin sulfate, which is inside the endothelial tissue. Calcium, a positive ion, can make these two negative ions connect and thus increase the chance of forming plaques in arteries. This is one reason that calcium should not be taken in megadosages.
MONOGRAPH
Inositol Hexaniacinate
{Reprinted by permission o/Alternative Medicine Review, 1998;3(3). Copyright © Thome Research, Inc. All rights reserved.)
Inositol hexaniacinate (IHN) is the hexanicotinic acid ester of meso-inositol. |
Jonathan V. Wright, M.D. and Alan R. Gaby, M.D.
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 We usually recommend glucosamine sulfate for our patients, without the addition of chondroitin sulfate. However, we have no objection if someone wants to use the more expensive combination treatment.
Vitamin E and Selenium
Vitamin E has a mild anti-inflammatory effect, similar to that of aspirin-like drugs. Although vitamin E is not nearly as strong as aspirin and related drugs, it also doesn't produce any of the side effects associated with these drugs. |
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