| When fats are no longer properly digested, the fat-soluble vitamins A, D, E, K, which are normally stored in the liver, become deficient. This problem is made worse by eating low fat foods (see section 6 on Light Foods).
If vitamin A becomes deficient, for example, the epithelial cells, which form an essential part of all the organs, blood vessels, lymph vessels, etc., in the body, become damaged. This can cause practically any kind of disease known. Vitamin A is also necessary to maintain the cornea of the eye, allow for eyesight in dim light, and reduce the severity of microbial infection. | Dr. Steven R. Gundry See book keywords and concepts | With the exception of vitamin D, which your body can manufacture directly from sunlight, you must get the A, E, K, and other fat-soluble vitamins in your diet, and they must be consumed as or with fat. The fats that we used to consume as recently as fifty years ago came from animals that fed primarily on grass and leaves. Remember that carnivores get most of their micronutrients by consuming the fatty organs of their grass-eating prey, a fact critical to understanding this second innate drive to find fat. | Brenda Watson and Leonard Smith See book keywords and concepts | In addition to emulsifying fat, bile also lubricates the intestines, assists in absorption of fat-soluble vitamins, and promotes peristalsis (wavelike muscular movements in the intestines that keep your bowels moving on their way to the exit). Also, some toxins are carried out of the body in the bile through the stool.
Because bile links your liver, gallbladder, and digestive tract, people with liver problems frequendy have gallbladder issues and vice versa. They are also likely to have digestion problems. | Andreas Moritz See book keywords and concepts | Eventually, the body will run short of useful essential fats and fat-soluble vitamins. This prompts the liver to increase cholesterol production, causing yet more gallstones to be formed.
The less fat the body receives with the food, the worse the situation becomes. However, since fats cannot be digested properly anymore, the body enters a vicious cycle, which in most cases can only be stopped by removing all gallstones from the liver and gallbladder and then gradually increasing fat intake to normal levels. | | The main reason we need fats in our diet is not so much to meet our need for cholesterol, but to help digest and absorb other foods and to derive fat-soluble vitamins. The liver raises cholesterol production to abnormal levels only when the basal membranes of the sinusoids are plastered with protein deposits.
Other factors that generate excessive amounts of protein in the blood include stress, smoking, and drinking alcohol and caffeinated beverages. | Ann M. Coulston and Carol J. Boushey See book keywords and concepts | Because fat-soluble vitamins are also malabsorbed in this disorder, vitamin K deficiency may occur, resulting in an increased risk for bruising and bleeding. Vitamin E deficiency may also occur, resulting in a hemolytic anemia and jaundice.
5. | Brenda Watson and Leonard Smith See book keywords and concepts | Fat-soluble toxins, such as fat-soluble vitamins, are larger-chain molecules and enter the lymph system. From there they are carried eventually into the blood in the chest cavity. All environmental toxins such as solvents, pesticides, food additives, and air pollution can be either fat-soluble or water-soluble, depending on their specific chemical makeup. Once in the blood, either directly through the intestinal wall or via the lymph system, the toxins will make their way to the liver. See the illustration on page 86 to put this into perspective. | | The liver, which is the largest internal organ, performs many tasks—metabolizes carbohydrates, fats, and proteins; stores substances such as glycogen and fat-soluble vitamins; filters blood; and destroys toxic chemicals. As a result, it affects virtually every other organ and system in the body.
Love Your Liver
The liver is more than a washing machine for blood; it carries on many important metabolic activities—performing some five hundred other bodily functions, in fact (the most of any organ). | Andreas Moritz See book keywords and concepts | What applies to vitamin K also applies to all other fat-soluble vitamins, including vitamins A, E, and D. The small intestine can only absorb vitamin A and carotene sufficiently if fat absorption is normal. If vitamin A absorption is insufficient, the epithelial cells become damaged. These cells form an essential part of all the organs, blood vessels, lymph vessels, and so on in the body. Vitamin A is also necessary to maintain healthy eyes and protect against or reduce microbial infection. Vitamin D is essential for calcification of bones and teeth. | Hyla Cass See book keywords and concepts | It depletes the fat-soluble vitamins A, D, E, and K, as well as beta-carotene, calcium, and phosphorus. It should not be combined with stool softeners, which may increase its absorption into the body—not good, since mineral oil is toxic when taken internally.
PRESCRIPTIONS FOR CHRONIC CONSTIPATION
Chronic constipation may be the doctor's diagnosis when you have, for three or more months over the last twelve, had three or fewer bowel movements a week; bloating; hard stools; and a feeling that the colon never empties all the way. | Herbert Ross, DC with Keri Brenner, L.Ac. See book keywords and concepts | Lindsey Berk-son, DC, offer the following recommendations and precautions:
¦ Nutritional supplements should be taken with meals to promote increased absorption. fat-soluble vitamins (such as vitamins A and E, beta-carotene, and the essential fatty acids linoleic and alpha-linolenic acid) should be taken during the day with the meal that contains the most fat.
¦ Amino acid supplements should be taken on an empty stomach at least 1 hour before or after a meal, and taken with fruit juice to help promote absorption. | Mark Sircus See book keywords and concepts | Likewise, the intestinal mucosa (mucous membrane) requires fat-soluble vitamins and adequate dietary cholesterol to maintain proper integrity so that it passes only those nutrients the body needs, while at the same time keeping out toxins and large, undigested proteins that can cause allergic reactions.
Minerals may "compete" for receptor sites. Excess calcium may impede the absorption of manganese, for example. | Ann M. Coulston and Carol J. Boushey See book keywords and concepts | MALNUTRITION IN CYSTIC FIBROSIS
CF is associated with an increased risk of protein-calorie malnutrition, as well as deficiencies in fat-soluble vitamins and other micronutrients. Malnutrition associated with CF is characterized by its early onset and is often present at the time of CF diagnosis. At the mild end of the malnutrition spectrum, CF patients may have depleted stores or low circulating concentrations of a given nutrient, but no associated signs or symptoms. | | Micronutrient deficiencies (e.g., fat-soluble vitamins) Energy expenditure Eating behaviors nutrient deficiencies in patients with CF [55]. The ductular cells of the pancreas respond to stimulation with secretin by producing a high-volume, bicarbonate-rich secretion. This secretion functions to neutralize gastric acid, thus enabling the pancreatic digestive enzymes to function at their pH optimum. The abnormal chloride transport caused by the defective CFTR protein leads to thickened secretions that obstruct the pancreatic ducts and prevent the secretion of enzymes and bicarbonate. | | These may affect compliance with prescribed medications such as pancreatic enzymes and fat-soluble vitamins. In addition, acceptance and understanding by teachers and fellow students may be lacking, further stressing a child with CF. Encouraging children to help in meal planning and preparation may be helpful in improving food intake. c. Adolescence
This stage represents another vulnerable period of developing malnutrition because of increased nutritional requirements associated with accelerated growth, endocrine development, and high levels of physical activity. | | Additional supplementation with fat-soluble vitamins is needed (Table 6).
CF patients are at risk of hyponatremia because of salt loss through the skin. Infants with CF should receive salt supplementation (1/8 tsp per day). Older children and adults are advised to consume a high-salt diet, especially during summer months and for those who live in hot climates.
Vitamin A (IU)
Vitamin E (IU)
Vitamin D (IU)
Vitamin K (mg)a
0-12 months
1,500
40-50
400
0.3-0.5
1-3 years
5,000
80-150
400-800
0.3-0.5
4-8 years
5,000-10,000
100-200
400-800
0.3-0. | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | The fat malabsorption associated with CF often leads to a deficiency of fat-soluble vitamins. Oral supplementation of these nutrients is considered crucial to maintaining good nutritional status.18 Current recommendations for supplementation are as follows: vitamin A (page 595), 5,000 to 10,000 IU/day; vitamin D (page 607), 1,000 to 2,000 IU/day; vitamin E (page 609), 100 to 300 IU/day; and vitamin K (page 612), 5 mg every three days. Of the water-soluble vitamins, only vitamin B12 (page 601) is poorly absorbed in cystic fibrosis,19 and taking pancreatic enzymes helps prevent B12 deficiencies. | Earl Mindell, R.Ph., Ph.D. See book keywords and concepts | On the other hand, fat-soluble vitamins (A,D,E, and K) are stored in the liver. fat-soluble vitamins cannot be properly absorbed by the body unless we consume an adequate supply of fat and minerals.
Water-soluble vitamins are usually measured in milligrams or micrograms. fat-soluble vitamins are usually measured in International Units or IUs.
Minerals—Minerals are naturally occurring chemical elements found throughout the human body in the bones, muscles, teeth, blood and nerve cells. | by Michael Murray, N.D. and Joseph Pizzorno, N.D. See book keywords and concepts | | Vitamin D has the greatest potential to cause toxicity in comparison to other fat-soluble vitamins. Supplementation greater than 400 IU per day, the RDA for children, appears to be unwarranted. vitamin d content of selected foods, in international units (i.u. | Abram Hoffer, PhD, MD, FRCP(C) and Dr. Jonathan Prousjy, DPHE, DSC, ND, FRSH See book keywords and concepts | Fat-soluble vitamins can build up and one has to be more cautious about using high doses. But even here the dangers of these vitamins, such as vitamin D-3 and vitamin A, have been grossly exaggerated.
Orthomolecular Medicine
Dr Linus Pauling, in his fundamental study of "orthomolecular" nutrition and in his celebrated book Vitamin C and the Common Cold, has shown how the human body lost its ability during evolution to make certain nutrients. About 60 million years ago man, other primates, the guinea pig, and an Indian fruit-eating bat lost the ability to make vitamin C. | | Bile is useful in absorbing fat-soluble vitamins and helps to bind many toxic substances and eliminate them from the body. The liver's metabolic functions include carbohydrate, fat, and protein metabolism; the storage of vitamins and minerals; the formation of vital physiologic factors; and the detoxification of foreign or endogenous chemical compounds.
Dosage
The best type of liver extract are hydrolyzed (water is added to it) and are known as "liquid liver extracts." Make sure that at least 3 to 4 mg of heme iron is provided per capsule of the liver extract. | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | Fat malabsorption in pancreatic insufficiency may result in deficiencies of fat-soluble vitamins, and these deficiencies may not always be prevented by enzyme supplementation.44' 45' 46 One controlled study found that patients with chronic pancreatitis had vision abnormalities that are associated with vitamin A deficiency.47 A controlled study of patients with steatorrhea found that a water-soluble form of vitamin A (page 595) was easier to absorb than conventional fat-soluble forms of vitamin A, resulting in vitamin A absorption equal to that of healthy people. | | Although doctors sometimes recommend supplementation with fat-soluble vitamins for people with pancreatitis,51 no research has investigated the benefits of these supplements.
Pancreatic enzymes are also necessary for the absorption of vitamin B12 (page 601).52 While people with pancreatic insufficiency have some malabsorption of this vitamin, true deficiency is considered rare.53'54'55 No research has investigated whether long-term vitamin B12 supplementation is beneficial for chronic pancreatitis. | Kaayla T. Daniel, PhD, CCN See book keywords and concepts | Fats stave off food cravings, carry the fat-soluble vitamins A, D, E and K, facilitate mineral absorption, cushion vital organs, build hormones, contribute to moist, young-looking skin, and construct strong, flexible, fully functioning cell membranes. It's smart to appreciate fat—and no accident that fats make up more than 60 percent of the brain.13
Yet Americans demonize fat. Health-conscious consumers scarf down "low-fat" and "no-fat" products in the sure, though mistaken, belief that "less is more." Indeed fat has been blamed for nearly every ill that can befall the human body. | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | However, the absorption of minerals and fat-soluble vitamins (page 603) was also reduced by feeding animals large amounts of chitosan. 277 In studies in humans, chitosan did not reduce the absorption of dietary fat.278,279
Royal jelly (page 582) has prevented the cholesterol-elevating effect of nicotine280 and has lowered serum cholesterol in animal studies.281 Preliminary human trials have also found that royal jelly may lower cholesterol levels.282, 283 An analysis of cholesterol-lowering trials shows that 50 to 100 mg per day is the typical amount used in such research. | Phyllis A. Balch, CNC See book keywords and concepts | Taking one 1,200-milligram capsule before each meal helps in the digestion of fats and the absorption of fat-soluble vitamins.
Most lecithin is derived from soybeans, but recently egg lecithin has become popular. This type of lecithin is extracted from the yolks of fresh eggs. Egg lecithin may hold promise for those suffering from AIDS, herpes, chronic fatigue syndrome, and immune disorders associated with aging. Studies have shown that it works better for people with these disorders than soy lecithin does. | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | While no long-term studies of the effects of chitosan on human health have been done, animal studies suggest that this compound could inhibit the absorption of minerals (page 559) and fat-soluble vitamins (page 559). Adverse effects on the growth of children and on the outcome of pregnancy (page 363) ate also possible.1 In addition, although chitosan-included alterations in intestinal flora are believed to be beneficial, the possibility that these changes may have negative long-term consequences has not been ruled out. | Mary-Ann Shearer See book keywords and concepts | Next, fats play an essential role in the diet; they are needed to help with the absorption of the fat-soluble vitamins A, D, E, and K. I find it interesting that all fruits (see tables in the back) and vegetables contain vitamin A (actually beta-carotene, which is the precursor to vitamin A), which is a fat-soluble vitamin, along with fat—nature has made sure that the vitamin A is absorbable and assimilated because of the presence of fat. Also, fats are a source of essential fatty acids. | Ben-Erik van Wyk See book keywords and concepts | The vitamins of relevance to plant foods are divided into two main groups: fat-soluble vitamins (A, D, E and K) and water-soluble vitamins (B,, B2, B6, B12, biotin, C, folic acid, niacin and pantothenic acid). The recommended daily allowance (RDA) - the quantity needed to prevent deficiency - varies from country to country. RDAs allowed for labelling purposes in the European Union (EU) are given below.
Vitamin A
The chemical name for vitamin A is retinol. The original source of all retinol is provitamin A, better known as fi-carotene, and is found in plant pigments. |
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